E2 interaction and dimerization in the crystal structure of TRAF6

TRAF6 mediates Lys63 (K63)-linked polyubiquitination for NF-κB activation via its N-terminal RING and zinc finger domains. Here we report the crystal structures of TRAF6 and its complex with the ubiquitin conjugating enzyme (E2) Ubc13. The RING and zinc fingers of TRAF6 assume a rigid, strikingly el...

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Detalhes bibliográficos
Main Authors: Yin, Qian, Lin, Su-Chang, Lamothe, Betty, Lu, Miao, Lo, Yu-Chih, Hura, Gregory, Zheng, Lixin, Rich, Rebecca L., Campos, Alejandro D., Myszka, David G., Lenardo, Michael J., Darnay, Bryant G., Wu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834951/
https://ncbi.nlm.nih.gov/pubmed/19465916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1605
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