Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: A patch clamp and simulation study

Benzodiazepines (BDZs) are GABA(A) receptor modulators with anxiolytic, hypnotic, and anticonvulsant properties. BDZs are understood to potentiate GABA(A) receptor function by increasing channel opening frequency, in contrast to barbiturates, which increase channel open duration. However, the in vit...

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Autores principales: Bianchi, Matt T., Botzolakis, Emmanuel J., Lagrange, Andre H., Macdonald, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834588/
https://ncbi.nlm.nih.gov/pubmed/19447010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2009.03.007
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