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The PI3K Pathway As Drug Target in Human Cancer
The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, including somatic mutation and amplification of genes encoding key components. In addition, PI3K signaling...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Clinical Oncology
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834432/ https://ncbi.nlm.nih.gov/pubmed/20085938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.3641 |
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