Structure Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections

Structure-activity relationship studies were carried out by chemical modification of manzamine A (1), 8-hydroxymanzamine A (2), manzamine F (14), and ircinol isolated from the sponge Acanthostrongylophora. The derived analogues were evaluated for antimalarial, antimicrobial, and antineuroinflammator...

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Main Authors: Peng, Jiangnan, Kudrimoti, Sucheta, Prasanna, Sivaprakasam, Odde, Srinivas, Doerksen, Robert J., Pennaka, Hari K, Choo, Yeun-Mun, Rao, Karumanchi V., Tekwani, Babu L., Madgula, Vamsi, Khan, Shabana I., Wang, Bin, Mayer, Alejandro M. S., Jacob, Melissa R., Tu, Lan Chun, Gertsch, Jürg, Hamann, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834284/
https://ncbi.nlm.nih.gov/pubmed/20017491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900672t
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