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Structure–activity relationship studies of manzamine A: Amidation of positions 6 and 8 of the β-carboline moiety
Twenty manzamine amides were synthesized and evaluated for in vitro antimalarial and antimicrobial activities. The amides of manzamine A (1) showed significantly reduced cytotoxicity against Vero cells, although were less active than 1. The structure–activity analysis showed that linear, short alkyl...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4883699/ https://ncbi.nlm.nih.gov/pubmed/19833520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.09.026 |
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