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2-N-Methyl Modifications and SAR Studies of Manzamine A

Quaternary carbolinium salts have been reported to show improved antimalarial activity and reduced cytotoxicity as compared to electronically neutral β-carbolines. In this study mono- and di-methylated quaternary carbolinium cations of manzamine A were synthesized and evaluated for their in vitro an...

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Hlavní autoři: Ibrahim, Mohamed A., Shilabin, Abbas G., Prasanna, Sivaprakasam, Jacob, Melissa, Khan, Shabana I., Doerksen, Robert J., Hamann, Mark T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547340/
https://ncbi.nlm.nih.gov/pubmed/18595720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.05.079
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