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2-N-Methyl Modifications and SAR Studies of Manzamine A
Quaternary carbolinium salts have been reported to show improved antimalarial activity and reduced cytotoxicity as compared to electronically neutral β-carbolines. In this study mono- and di-methylated quaternary carbolinium cations of manzamine A were synthesized and evaluated for their in vitro an...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547340/ https://ncbi.nlm.nih.gov/pubmed/18595720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.05.079 |
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