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Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

There is a critical need for molecular imaging agents to detect cell surface integrin receptors that are present in human cancers. Previously, we used directed evolution to engineer knottin peptides that bind with low nM affinity to integrin receptors that are overexpressed on the surface of tumor c...

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書誌詳細
主要な著者: Kimura, Richard H, Cheng, Zhen, Gambhir, Sanjiv Sam, Cochran, Jennifer R
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833353/
https://ncbi.nlm.nih.gov/pubmed/19276378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2495
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