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Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

There is a critical need for molecular imaging agents to detect cell surface integrin receptors that are present in human cancers. Previously, we used directed evolution to engineer knottin peptides that bind with low nM affinity to integrin receptors that are overexpressed on the surface of tumor c...

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Autori principali: Kimura, Richard H, Cheng, Zhen, Gambhir, Sanjiv Sam, Cochran, Jennifer R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833353/
https://ncbi.nlm.nih.gov/pubmed/19276378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2495
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