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Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

There is a critical need for molecular imaging agents to detect cell surface integrin receptors that are present in human cancers. Previously, we used directed evolution to engineer knottin peptides that bind with low nM affinity to integrin receptors that are overexpressed on the surface of tumor c...

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Detalhes bibliográficos
Main Authors: Kimura, Richard H, Cheng, Zhen, Gambhir, Sanjiv Sam, Cochran, Jennifer R
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833353/
https://ncbi.nlm.nih.gov/pubmed/19276378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2495
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