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A dual-labeled knottin peptide for PET and near-infrared fluorescence imaging of integrin expression in living subjects
Previously, we used directed evolution to engineer mutants of the Ecballium elaterium trypsin inhibitor (EETI-II) knottin that bind to α(v)β(3) and α(v)β(5) integrin receptors with low nanomolar affinity, and showed that Cy5.5- or (64)Cu-DOTA-labeled knottin peptides could be used to image integrin...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3004996/ https://ncbi.nlm.nih.gov/pubmed/20131753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9003102 |
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