Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4(+) T-cell responses

BACKGROUND: Disease recurrence in patients with acute myeloid leukemia may be partially explained by the escape of leukemic blasts from CD4(+) T-cell recognition. The current study investigates the role of aberrant HLA class II antigen presentation on leukemic blasts by determining both the clinical...

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Main Authors: van Luijn, Marvin M., Chamuleau, Martine E.D., Thompson, James A., Ostrand-Rosenberg, Suzanne, Westers, Theresia M., Souwer, Yuri, Ossenkoppele, Gert J., van Ham, S. Marieke, van de Loosdrecht, Arjan A.
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2010
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833080/
https://ncbi.nlm.nih.gov/pubmed/19903675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.010595
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