Alternative Ii-independent antigen-processing pathway in leukemic blasts involves TAP-dependent peptide loading of HLA class II complexes

During HLA class II synthesis in antigen-presenting cells, the invariant chain (Ii) not only stabilizes HLA class II complexes in the endoplasmic reticulum, but also mediates their transport to specialized lysosomal antigen-loading compartments termed MIICs. This study explores an alternative HLA cl...

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Detalhes bibliográficos
Main Authors: van Luijn, Marvin M., Chamuleau, Martine E. D., Ressing, Maaike E., Wiertz, Emmanuel J., Ostrand-Rosenberg, Suzanne, Souwer, Yuri, Zevenbergen, Adri, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., van Ham, S. Marieke
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945475/
https://ncbi.nlm.nih.gov/pubmed/20820776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-010-0908-z
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