Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD(+)-dependent histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed in the nucleus. However, adult cardiomyocytes predominantly express SIRT1 in the cytoplasm, and its function has...

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Bibliografiske detaljer
Main Authors: Tanno, Masaya, Kuno, Atsushi, Yano, Toshiyuki, Miura, Tetsuji, Hisahara, Shin, Ishikawa, Satoko, Shimamoto, Kazuaki, Horio, Yoshiyuki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832987/
https://ncbi.nlm.nih.gov/pubmed/20089851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090266
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