Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein

Cardiomyopathy is the main cause of death in Duchenne muscular dystrophy. Here, we show that oral administration of resveratrol, which leads to activation of an NAD(+)-dependent protein deacetylase SIRT1, suppresses cardiac hypertrophy and fibrosis and restores cardiac diastolic function in dystroph...

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Главные авторы: Kuno, Atsushi, Hori, Yusuke S., Hosoda, Ryusuke, Tanno, Masaya, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581415/
https://ncbi.nlm.nih.gov/pubmed/23297412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392050
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