Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein

Cardiomyopathy is the main cause of death in Duchenne muscular dystrophy. Here, we show that oral administration of resveratrol, which leads to activation of an NAD(+)-dependent protein deacetylase SIRT1, suppresses cardiac hypertrophy and fibrosis and restores cardiac diastolic function in dystroph...

Full description

Saved in:
Bibliographic Details
Main Authors: Kuno, Atsushi, Hori, Yusuke S., Hosoda, Ryusuke, Tanno, Masaya, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581415/
https://ncbi.nlm.nih.gov/pubmed/23297412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392050
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items