Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein

Cardiomyopathy is the main cause of death in Duchenne muscular dystrophy. Here, we show that oral administration of resveratrol, which leads to activation of an NAD(+)-dependent protein deacetylase SIRT1, suppresses cardiac hypertrophy and fibrosis and restores cardiac diastolic function in dystroph...

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Main Authors: Kuno, Atsushi, Hori, Yusuke S., Hosoda, Ryusuke, Tanno, Masaya, Miura, Tetsuji, Shimamoto, Kazuaki, Horio, Yoshiyuki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581415/
https://ncbi.nlm.nih.gov/pubmed/23297412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392050
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