Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

Previously we demonstrated that c-Jun N-terminal kinase (JNK) plays a central role in acetaminophen (APAP)-induced liver injury. In the current work, we examined other possible signaling pathways that may also contribute to APAP hepatotoxicity. APAP treatment to mice caused glycogen synthase kinase-...

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Autori principali: Shinohara, Mie, Ybanez, Maria D., Win, Sanda, Than, Tin Aung, Jain, Shilpa, Gaarde, William A., Han, Derick, Kaplowitz, Neil
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832976/
https://ncbi.nlm.nih.gov/pubmed/20061376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054999
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