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PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832956/ https://ncbi.nlm.nih.gov/pubmed/20064938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077834 |
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