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Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities

Peroxiredoxin 6 (Prdx6) differs from other mammalian peroxiredoxins both in its ability to reduce phospholipid hydroperoxides at neutral pH and in having phospholipase A(2) (PLA(2)) activity that is maximal at acidic pH. We previously showed an active site C47 for peroxidase activity and a catalytic...

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Detalhes bibliográficos
Main Authors: Manevich, Yefim, Shuvaeva, Tea, Dodia, Chandra, Kazi, Altaf, Feinstein, Sheldon I., Fisher, Aron B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832859/
https://ncbi.nlm.nih.gov/pubmed/19236840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.02.008
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