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Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities

Peroxiredoxin 6 (Prdx6) differs from other mammalian peroxiredoxins both in its ability to reduce phospholipid hydroperoxides at neutral pH and in having phospholipase A(2) (PLA(2)) activity that is maximal at acidic pH. We previously showed an active site C47 for peroxidase activity and a catalytic...

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Bibliografski detalji
Glavni autori: Manevich, Yefim, Shuvaeva, Tea, Dodia, Chandra, Kazi, Altaf, Feinstein, Sheldon I., Fisher, Aron B.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832859/
https://ncbi.nlm.nih.gov/pubmed/19236840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.02.008
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