Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5′ olfactory receptor gene cluster

In a genome-wide association study of 848 blacks with sickle cell anemia, we identified single nucleotide polymorphisms (SNPs) associated with fetal hemoglobin concentration. The most significant SNPs in a discovery sample were tested in a replication set of 305 blacks with sickle cell anemia and in...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Solovieff, Nadia, Milton, Jacqueline N., Hartley, Stephen W., Sherva, Richard, Sebastiani, Paola, Dworkis, Daniel A., Klings, Elizabeth S., Farrer, Lindsay A., Garrett, Melanie E., Ashley-Koch, Allison, Telen, Marilyn J., Fucharoen, Supan, Ha, Shau Yin, Li, Chi-Kong, Chui, David H. K., Baldwin, Clinton T., Steinberg, Martin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832816/
https://ncbi.nlm.nih.gov/pubmed/20018918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-239517
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi