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Probing the effect of amino-terminal truncation for Aβ(1–40) peptides

We examine the effect of deletion of the amino-terminal (residues 1 to 9) on the structure and energetics of Aβ(1–40) peptides. To this end, we use replica exchange molecular dynamics to compare the conformational ensembles of Aβ(1–40) and amino-truncated Aβ(10–40) monomers and dimers. Overall, the...

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Autors principals: Takeda, Takako, Klimov, Dmitri K.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832594/
https://ncbi.nlm.nih.gov/pubmed/19419218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9016773
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