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Computational backbone mutagenesis of Aβ peptides: Probing the role of backbone hydrogen bonds in aggregation
Using REMD and united atom implicit solvent model we examine the role of backbone hydrogen bonds (HBs) in Aβ aggregation. The importance of HBs appears to depend on the aggregation stage. The backbone HBs have little effect on the stability of Aβ dimers or on their aggregation interface. The HBs als...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862262/ https://ncbi.nlm.nih.gov/pubmed/20302321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp911533q |
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