Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations

Nonsense mutations promote premature translational termination and represent the underlying cause of a large number of human genetic diseases. The aminoglycoside antibiotic gentamicin has the ability to allow the mammalian ribosome to read past a false-stop signal and generate full-length functional...

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Hauptverfasser: Nudelman, Igor, Rebibo-Sabbah, Annie, Cherniavsky, Marina, Belakhov, Valery, Hainrichson, Mariana, Chen, Fuquan, Schacht, Jochen, Pilch, Daniel S., Ben-Yosef, Tamar, Baasov, Timor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832307/
https://ncbi.nlm.nih.gov/pubmed/19309154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801640k
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