COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems

Bone marrow (BM)–derived hematopoietic cells, which are major components of tumor stroma, determine the tumor microenvironment and regulate tumor phenotypes. Cyclooxygenase (COX)−2 and endogenous prostaglandins are important determinants for tumor growth and tumor-associated angiogenesis; however, t...

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Autori principali: Katoh, Hiroshi, Hosono, Kanako, Ito, Yoshiya, Suzuki, Tatsunori, Ogawa, Yasufumi, Kubo, Hidefumi, Kamata, Hiroki, Mishima, Toshiaki, Tamaki, Hideaki, Sakagami, Hiroyuki, Sugimoto, Yukihiko, Narumiya, Shuh, Watanabe, Masahiko, Majima, Masataka
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832166/
https://ncbi.nlm.nih.gov/pubmed/20110411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090607
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