Aging Fibroblasts Resist Phenotypic Maturation Because of Impaired Hyaluronan-Dependent CD44/Epidermal Growth Factor Receptor Signaling

Fibroblast differentiation into myofibroblasts is a key event during normal wound repair. We have previously demonstrated an age-related defect in this process associated with impaired synthesis of hyaluronan (HA) synthase (HAS) 2 but failed to prescribe its role in a mechanistic sense. Here we demo...

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Detalhes bibliográficos
Main Authors: Simpson, Russell M.L., Wells, Alan, Thomas, David, Stephens, Philip, Steadman, Robert, Phillips, Aled
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832144/
https://ncbi.nlm.nih.gov/pubmed/20093489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090802
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