Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants

MEC1, the essential yeast homolog of the human ATR/ATM genes, controls the S-phase checkpoint and prevents replication fork collapse at slow zones of DNA replication. The viability of hypomorphic mec1-21 is reduced in the rad52 mutant, defective in homologous recombination, suggesting that replicati...

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Main Authors: Fasullo, Michael, Tsaponina, Olga, Sun, Mingzeng, Chabes, Andrei
格式: Artigo
語言:Inglês
出版: Oxford University Press 2010
主題:
Molecular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831302/
https://ncbi.nlm.nih.gov/pubmed/19965764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1064
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