Non-consensus GLI binding sites in Hedgehog target gene regulation

BACKGROUND: The GLI transcription factors, mediators of the hedgehog signal bind with high affinity to the consensus sequence GACCACCCA. The affinity of variant single substitutions in GLI binding sites has been measured systematically, but the affinities of the variant binding sites appears low com...

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Autors principals: Winklmayr, Martina, Schmid, Carmen, Laner-Plamberger, Sandra, Kaser, Alexandra, Aberger, Fritz, Eichberger, Thomas, Frischauf, Anna-Maria
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830928/
https://ncbi.nlm.nih.gov/pubmed/20070907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-2
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