Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment strategies. We therefore conducted a kinome-wide small interfering RNA (siRNA) lethality study in myeloma tumor lines bearing common t(4;14), t(14;16), and t(11;14) trans...

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Auteurs principaux: Tiedemann, Rodger E., Zhu, Yuan Xiao, Schmidt, Jessica, Yin, Hongwei, Shi, Chang-Xin, Que, Qiang, Basu, Gargi, Azorsa, David, Perkins, Louise M., Braggio, Esteban, Fonseca, Rafael, Bergsagel, P. Leif, Mousses, Spyro, Stewart, A. Keith
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830764/
https://ncbi.nlm.nih.gov/pubmed/19996089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-243980
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