Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes

During the course of homing to lymph nodes (LNs), T cells undergo a multistep adhesion cascade that culminates in a lymphocyte function-associated antigen 1 (LFA-1)–dependent firm adhesion to the luminal surface of high endothelial venules (HEVs). The importance of LFA-1 affinity regulation in suppo...

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Autors principals: Park, Eun Jeong, Peixoto, António, Imai, Yoichi, Goodarzi, Ahmad, Cheng, Guiying, Carman, Christopher V., von Andrian, Ulrich H., Shimaoka, Motomu
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830762/
https://ncbi.nlm.nih.gov/pubmed/20023213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237917
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