Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α(4) integrins

α(4) integrins play a pivotal role in leukocyte migration and tissue-specific homing. The ability of integrins to bind ligand is dynamically regulated by activation-dependent conformational changes triggered in the cytoplasmic domain. An NMR solution structure defined a putative membrane-proximal sa...

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Main Authors: Imai, Yoichi, Park, Eun Jeong, Peer, Dan, Peixoto, António, Cheng, Guiying, von Andrian, Ulrich H., Carman, Christopher V., Shimaoka, Motomu
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597606/
https://ncbi.nlm.nih.gov/pubmed/18809756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144543
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