טוען...
Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α(4) integrins
α(4) integrins play a pivotal role in leukocyte migration and tissue-specific homing. The ability of integrins to bind ligand is dynamically regulated by activation-dependent conformational changes triggered in the cytoplasmic domain. An NMR solution structure defined a putative membrane-proximal sa...
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| Main Authors: | , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society of Hematology
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597606/ https://ncbi.nlm.nih.gov/pubmed/18809756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144543 |
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