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Identification of L-Methionine-S-Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine

The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine sy...

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Autors principals: Rowe, W. Bruce, Meister, Alton
Format: Artigo
Idioma:Inglês
Publicat: 1970
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC283073/
https://ncbi.nlm.nih.gov/pubmed/4393740
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