Identification of L-Methionine-S-Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine
The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine sy...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1970
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4393740/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.66.2.500 |
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