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Identification of L-Methionine-S-Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine

The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine sy...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Rowe, W. Bruce, Meister, Alton
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 1970
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283073/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4393740/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.66.2.500
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