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Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry

Entry of herpes simplex virus (HSV) occurs either by fusion at the plasma membrane or by endocytosis and fusion with an endosome. Binding of glycoprotein D (gD) to a receptor such as nectin-1 is essential in both cases. We show that virion gD triggered the rapid down-regulation of nectin-1 with kine...

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Detalhes bibliográficos
Main Authors: Stiles, Katie M., Krummenacher, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830393/
https://ncbi.nlm.nih.gov/pubmed/20089288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.12.034
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