Herpes Simplex Virus Glycoprotein D Interferes with Binding of Herpesvirus Entry Mediator to Its Ligands through Downregulation and Direct Competition

To initiate membrane fusion and virus entry, herpes simplex virus (HSV) gD binds to a cellular receptor such as herpesvirus entry mediator (HVEM). HVEM is a tumor necrosis factor (TNF) receptor family member with four natural ligands that either stimulate (LIGHT and LTα) or inhibit (BTLA and CD160)...

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Detalhes bibliográficos
Main Authors: Stiles, Katie M., Whitbeck, J. Charles, Lou, Huan, Cohen, Gary H., Eisenberg, Roselyn J., Krummenacher, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977867/
https://ncbi.nlm.nih.gov/pubmed/20826693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01550-10
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