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Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombination
V(D)J recombination, the process that rearranges gene segments to assemble mature antigen receptor genes, relies on a recombinase comprising the RAG1 and RAG2 proteins. RAG1 is a multi-functional enzyme including DNA binding and cleavage as well as ubiquitin ligase activities, all of which appear to...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830333/ https://ncbi.nlm.nih.gov/pubmed/20116856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.01.004 |
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