Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia. We wanted to define whether neurons require selenoprotein expression and which selenoproteins are most important, and explore the possible pathomechanism. Therefore, we abrogated the expressio...

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Hauptverfasser: Wirth, Eva K., Conrad, Marcus, Winterer, Jochen, Wozny, Christian, Carlson, Bradley A., Roth, Stephan, Schmitz, Dietmar, Bornkamm, Georg W., Coppola, Vincenzo, Tessarollo, Lino, Schomburg, Lutz, Köhrle, Josef, Hatfield, Dolph L., Schweizer, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Federation of American Societies for Experimental Biology 2010
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830140/
https://ncbi.nlm.nih.gov/pubmed/19890015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-143974
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