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Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schomburg, Lutz, Schweizer, Ulrich, Holtmann, Bettina, Flohé, Leopold, Sendtner, Michael, Köhrle, Josef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223208/
https://ncbi.nlm.nih.gov/pubmed/12521380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021853
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