Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P

Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading. We hypothesized that biosynthesis of the selenium (Se) transporter selenoprotein P (SELENOP) i...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Renko, Kostja, Martitz, Janine, Hybsier, Sandra, Heynisch, Bjoern, Voss, Linn, Everley, Robert A., Gygi, Steven P., Stoedter, Mette, Wisniewska, Monika, Köhrle, Josef, Gladyshev, Vadim N., Schomburg, Lutz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491492/
https://ncbi.nlm.nih.gov/pubmed/28663583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04586-9
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