Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia. We wanted to define whether neurons require selenoprotein expression and which selenoproteins are most important, and explore the possible pathomechanism. Therefore, we abrogated the expressio...

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Autors principals: Wirth, Eva K., Conrad, Marcus, Winterer, Jochen, Wozny, Christian, Carlson, Bradley A., Roth, Stephan, Schmitz, Dietmar, Bornkamm, Georg W., Coppola, Vincenzo, Tessarollo, Lino, Schomburg, Lutz, Köhrle, Josef, Hatfield, Dolph L., Schweizer, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2010
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830140/
https://ncbi.nlm.nih.gov/pubmed/19890015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-143974
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