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Simulation of Spontaneous Substrate Binding Revealing the Binding Pathway and Mechanism and Initial Conformational Response of GlpT

Glycerol-3-phosphate transporter (GlpT) mediates the import of glycerol-3-phosphate (G3P) using the gradient of inorganic phosphate (P(i)). In order to study the process and mechanism of substrate binding and to investigate the protein's initial response, equilibrium simulations of wild-type an...

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Détails bibliographiques
Auteurs principaux: Enkavi, Giray, Tajkhorshid, Emad
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829668/
https://ncbi.nlm.nih.gov/pubmed/20058936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901412a
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