Unstable Hemoglobins: The Role of Heme Loss in Heinz Body Formation

Mutant, unstable hemoglobins precipitate as Heinz bodies in circulating red blood cells resulting in their premature hemolysis. We stress that generally these hemoglobins contain amino acid substitutions in the β-chain of globin near the heme pocket, and demonstrate that heme binding suffers thereby...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Jacob, Harry, Winterhalter, Kaspar
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1970
Onderwerpen:	Biological Sciences: Biochemistry
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5267148/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.65.3.697
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