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Auger Electron-Induced Double-Strand Breaks Depend on DNA Topology

From a structural perspective, the factors controlling and the mechanisms underlying the toxic effects of ionizing radiation remain elusive. We have studied the consequences of superhelical/torsional stress on the magnitude and mechanism of DSBs induced by low-energy, short-range, high-LET Auger ele...

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Detalhes bibliográficos
Main Authors: Balagurumoorthy, Pichumani, Chen, Kai, Adelstein, S. James, Kassis, Amin I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829305/
https://ncbi.nlm.nih.gov/pubmed/18582152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1072.1
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