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DNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: Role of DNA topology

PURPOSE: To determine double-strand-break (DSB) yields produced by decay of minor-groove-bound (123)I-labeled Hoechst 33342 ((123)IEH) in supercoiled (SC) and linear (L) forms of pUC19 DNA, to compare strand-break efficiency of (123)IEH with that of (125)IEH, and to examine the role of DNA topology...

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Detalhes bibliográficos
Main Authors: BALAGURUMOORTHY, PICHUMANI, WANG, KETAI, ADELSTEIN, S. JAMES, KASSIS, AMIN I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829301/
https://ncbi.nlm.nih.gov/pubmed/19061121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09553000802512568
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