Protein-Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5’ Leaders by Bacterial Ribonuclease P

Bacterial ribonuclease P (RNase P) catalyzes cleavage of 5’ leader sequences from precursor tRNAs (pre-tRNAs). Previously, all known substrate nucleotide specificity in this system derived from RNA-RNA interactions with the RNase P RNA subunit (PRNA). Here, we demonstrate that pre-tRNA binding affin...

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Hauptverfasser: Koutmou, Kristin S., Zahler, Nathan H., Kurz, Jeffrey C., Campbell, Frank E., Harris, Michael E., Fierke, Carol A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829246/
https://ncbi.nlm.nih.gov/pubmed/19932118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.039
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