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Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca(2+) sensitivity and induces vasoconstriction in porcine pulmonary arteries

BACKGROUND AND PURPOSE: Thrombus formation is commonly associated with pulmonary arterial hypertension (PAH). Thrombin may thus play an important role in the pathogenesis and pathophysiology of PAH. Hence, we investigated the contractile effects of thrombin and its mechanism in pulmonary artery. EXP...

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Bibliografische gegevens
Hoofdauteurs: Maki, Jun, Hirano, Mayumi, Hoka, Sumio, Kanaide, Hideo, Hirano, Katsuya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829217/
https://ncbi.nlm.nih.gov/pubmed/20128804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00591.x
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