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Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca(2+) sensitivity and induces vasoconstriction in porcine pulmonary arteries

BACKGROUND AND PURPOSE: Thrombus formation is commonly associated with pulmonary arterial hypertension (PAH). Thrombin may thus play an important role in the pathogenesis and pathophysiology of PAH. Hence, we investigated the contractile effects of thrombin and its mechanism in pulmonary artery. EXP...

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Bibliografiske detaljer
Main Authors: Maki, Jun, Hirano, Mayumi, Hoka, Sumio, Kanaide, Hideo, Hirano, Katsuya
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829217/
https://ncbi.nlm.nih.gov/pubmed/20128804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00591.x
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