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Theophylline attenuates Ca(2+) sensitivity and modulates BK channels in porcine tracheal smooth muscle

1. Theophylline, a nonselective phosphodiesterase inhibitor, has long been regarded as a major bronchodilator in the treatment of human asthma. Using front-surface fluorometry with fura-2 and α-toxin permeabilization, the effects of theophylline on intracellular Ca(2+) concentration ([Ca(2+)](i)), t...

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Main Authors: Ise, Shinji, Nishimura, Junji, Hirano, Katsuya, Hara, Nobuyuki, Kanaide, Hideo
Formato: Artigo
Idioma:Inglês
Publicado: 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574100/
https://ncbi.nlm.nih.gov/pubmed/14517178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705508
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