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GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells

Prion diseases differ from other amyloid-associated protein misfolding diseases (e.g. Alzheimer's) because they are naturally transmitted between individuals and involve spread of protein aggregation between tissues. Factors underlying these features of prion diseases are poorly understood. Of...

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Detalhes bibliográficos
Main Authors: Speare, Jonathan O, Offerdahl, Danielle K, Hasenkrug, Aaron, Carmody, Aaron B, Baron, Gerald S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829165/
https://ncbi.nlm.nih.gov/pubmed/20057357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.392
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